UniProt functional annotation for Q3UH53



	UniProt functional annotation for Q3UH53

UniProt code: Q3UH53.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q8AV58}.

Subunit: Homodimer; mediates homophilic interactions to promote cell adhesion (PubMed:15703275). Interacts (via PDZ-binding motif) with MAGI1, MAGI2, DLG2, DLG3 and DLG4 (PubMed:20219992). {ECO:0000269|PubMed:15703275, ECO:0000269|PubMed:20219992}.

Subunit: [Isoform 2]: Does not mediate homophilic interactions (PubMed:15703275). {ECO:0000269|PubMed:15703275}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8AV58}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8AV58}. Cell junction, synapse {ECO:0000269|PubMed:20219992}.

Tissue specificity: Expressed by non-overlapping subsets of retinal neurons. Sdk1 and Sdk2 are expressed in non-overlapping subsets of interneurons and retinal ganglion cells (RGCs) that form synapses in distinct inner plexiform layer (IPL) sublaminae (at protein level). {ECO:0000269|PubMed:26287463}.

Developmental stage: Highly expressed in many fetal tissues, inlcuding kidney but shows markedly lower expression in adult organs. Expression in kidney is high throughout development with maximal expression occurring near birth. {ECO:0000269|PubMed:15213259}.

Domain: the PDZ-binding motif mediates interaction with PDZ domain- containing proteins MAGI1, MAGI2, DLG2, DLG3 and DLG4 and is required for is required for synaptic localization in photoreceptors. {ECO:0000250|UniProtKB:Q6V4S5}.

Domain: Ig-like C2-type domains 1 and 2 mediate homophilic interactions. {ECO:0000269|PubMed:15703275}.

Similarity: Belongs to the sidekick family. {ECO:0000305}.

Sequence caution: Sequence=BAC28069.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC28986.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. {ECO:0000250\|UniProtKB:Q8AV58}.


Subunit:		Homodimer; mediates homophilic interactions to promote cell adhesion (PubMed:15703275). Interacts (via PDZ-binding motif) with MAGI1, MAGI2, DLG2, DLG3 and DLG4 (PubMed:20219992). {ECO:0000269\|PubMed:15703275, ECO:0000269\|PubMed:20219992}.
Subunit:		[Isoform 2]: Does not mediate homophilic interactions (PubMed:15703275). {ECO:0000269\|PubMed:15703275}.
Subcellular location:		Cell membrane {ECO:0000250\|UniProtKB:Q8AV58}; Single-pass type I membrane protein {ECO:0000250\|UniProtKB:Q8AV58}. Cell junction, synapse {ECO:0000269\|PubMed:20219992}.
Tissue specificity:		Expressed by non-overlapping subsets of retinal neurons. Sdk1 and Sdk2 are expressed in non-overlapping subsets of interneurons and retinal ganglion cells (RGCs) that form synapses in distinct inner plexiform layer (IPL) sublaminae (at protein level). {ECO:0000269\|PubMed:26287463}.
Developmental stage:		Highly expressed in many fetal tissues, inlcuding kidney but shows markedly lower expression in adult organs. Expression in kidney is high throughout development with maximal expression occurring near birth. {ECO:0000269\|PubMed:15213259}.
Domain:		the PDZ-binding motif mediates interaction with PDZ domain- containing proteins MAGI1, MAGI2, DLG2, DLG3 and DLG4 and is required for is required for synaptic localization in photoreceptors. {ECO:0000250\|UniProtKB:Q6V4S5}.
Domain:		Ig-like C2-type domains 1 and 2 mediate homophilic interactions. {ECO:0000269\|PubMed:15703275}.
Similarity:		Belongs to the sidekick family. {ECO:0000305}.
Sequence caution:		Sequence=BAC28069.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC28986.1; Type=Erroneous initiation; Evidence={ECO:0000305};