UniProt functional annotation for O75317



	UniProt functional annotation for O75317

UniProt code: O75317.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity (PubMed:19075014, PubMed:27373336). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). {ECO:0000269|PubMed:19075014, ECO:0000269|PubMed:24145035, ECO:0000269|PubMed:27373336}.

Catalytic activity: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000269|PubMed:19075014};

Activity regulation: Activated by interaction with WDR20 and WDR48 through different allosteric mechanisms. {ECO:0000269|PubMed:20147737, ECO:0000269|PubMed:27373336}.

Subunit: Interacts with WDR48 (PubMed:19075014, PubMed:27650958, PubMed:27373336). Interacts with WDR20 (PubMed:20147737, PubMed:27373336). Component of the USP12/WDR20/WDR48 deubiquitinating complex (PubMed:20147737, PubMed:27373336). Interacts with PHLPP1 (PubMed:24145035). {ECO:0000269|PubMed:19075014, ECO:0000269|PubMed:20147737, ECO:0000269|PubMed:24145035, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:27650958}.

Miscellaneous: Knockdown of USP12 increases Akt activation. {ECO:0000269|PubMed:24145035}.

Similarity: Belongs to the peptidase C19 family. USP12/USP46 subfamily. {ECO:0000305}.

Sequence caution: Sequence=AAC23551.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity (PubMed:19075014, PubMed:27373336). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). {ECO:0000269\|PubMed:19075014, ECO:0000269\|PubMed:24145035, ECO:0000269\|PubMed:27373336}.


Catalytic activity:		Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000269\|PubMed:19075014};
Activity regulation:		Activated by interaction with WDR20 and WDR48 through different allosteric mechanisms. {ECO:0000269\|PubMed:20147737, ECO:0000269\|PubMed:27373336}.
Subunit:		Interacts with WDR48 (PubMed:19075014, PubMed:27650958, PubMed:27373336). Interacts with WDR20 (PubMed:20147737, PubMed:27373336). Component of the USP12/WDR20/WDR48 deubiquitinating complex (PubMed:20147737, PubMed:27373336). Interacts with PHLPP1 (PubMed:24145035). {ECO:0000269\|PubMed:19075014, ECO:0000269\|PubMed:20147737, ECO:0000269\|PubMed:24145035, ECO:0000269\|PubMed:27373336, ECO:0000269\|PubMed:27650958}.
Miscellaneous:		Knockdown of USP12 increases Akt activation. {ECO:0000269\|PubMed:24145035}.
Similarity:		Belongs to the peptidase C19 family. USP12/USP46 subfamily. {ECO:0000305}.
Sequence caution:		Sequence=AAC23551.1; Type=Erroneous initiation; Evidence={ECO:0000305};