PDBsum entry 5jyh

Toxin

PDB id: 5jyh

Contents

Protein chain

44 a.a.

PDB id:

5jyh

Name:

Toxin

Title:

Solution structure of hge36: scorpine-like peptide from hadrurus gertschi

Structure:

Hge-scorpine. Chain: a. Synonym: hg-scorpine-like 1,hgscplike1. Engineered: yes

Source:

Hadrurus gertschi. Scorpion. Organism_taxid: 380989. Expressed in: escherichia coli. Expression_system_taxid: 562

NMR struc:

20 models

Authors:

D.Flores-Solis,R.Rodriguez De La Vega,F.Del Rio-Portilla

Key ref:

D.Flores-Solis et al. (2016). Solution structure and antiparasitic activity of scorpine-like peptides from Hoffmannihadrurus gertschi. Febs Lett, 590, 2286-2296. PubMed id: 27314815 DOI: 10.1002/1873-3468.12255

Date:

13-May-16 Release date: 29-Jun-16

Protein chain

Q0GY40  (KBX3_HOFGE) -  Hge-scorpine from Hoffmannihadrurus gertschi

Seq: 95 a.a.

Struc: 44 a.a.

DOI no: 10.1002/1873-3468.12255

Febs Lett 590:2286-2296 (2016)

PubMed id: 27314815

Solution structure and antiparasitic activity of scorpine-like peptides from Hoffmannihadrurus gertschi.

D.Flores-Solis, Y.Toledano, O.Rodríguez-Lima, P.Cano-Sánchez, B.E.Ramírez-Cordero, A.Landa, R.C.Rodríguez de la Vega, F.Del Rio-Portilla.

ABSTRACT

Scorpine-like peptides are two domain peptides found in different scorpion venoms displaying various antimicrobial, cytolytic, and potassium channel-blocking activities. The relative contribution of each domain to their different activities remains to be elucidated. Here, we report the recombinant production, solution structure, and antiparasitic activity of Hge36, first identified as a naturally occurring truncated form of a Scorpine-like peptide from the venom of Hoffmannihadrurus gertschi. We also show that removing the first four residues from Hge36 renders a molecule with enhanced potassium channel-blocking and antiparasitic activities. Our results are important to rationalize the structure-function relationships of a pharmacologically versatile molecular scaffold.