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PDBsum entry 5jwm
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protein ligands Protein-protein interface(s) links
Transcription/transcription inhibitor PDB id
5jwm

 

 

 

 

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Contents
Protein chains
110 a.a.
Ligands
6ON
Waters ×205
PDB id:
5jwm
Name: Transcription/transcription inhibitor
Title: Bivalent bet bromodomain inhibition
Structure: Bromodomain-containing protein 4. Chain: a, b. Fragment: unp residues 333-460. Synonym: protein hunk1. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: brd4, hunk1. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.71Å     R-factor:   0.146     R-free:   0.168
Authors: H.-S.Seo,S.Dhe-Paganon
Key ref: M.Tanaka et al. (2016). Design and characterization of bivalent BET inhibitors. Nat Chem Biol, 12, 1089-1096. PubMed id: 27775715 DOI: 10.1038/nchembio.2209
Date:
12-May-16     Release date:   06-Jul-16    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
O60885  (BRD4_HUMAN) -  Bromodomain-containing protein 4 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1362 a.a.
110 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.?
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

 

 
DOI no: 10.1038/nchembio.2209 Nat Chem Biol 12:1089-1096 (2016)
PubMed id: 27775715  
 
 
Design and characterization of bivalent BET inhibitors.
M.Tanaka, J.M.Roberts, H.S.Seo, A.Souza, J.Paulk, T.G.Scott, S.L.DeAngelo, S.Dhe-Paganon, J.E.Bradner.
 
  ABSTRACT  
 
No abstract given.

 

 

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