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UniProt functional annotation for Q8TEK3 | ||
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| UniProt code: Q8TEK3. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
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| Catalytic activity: | |
Reaction=L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:60328, Rhea:RHEA-COMP:15549, Rhea:RHEA- COMP:15552, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.360; Evidence={ECO:0000255|PROSITE-ProRule:PRU00902, ECO:0000269|PubMed:12123582}; |
| Subunit: | |
Interacts with MLLT10. {ECO:0000269|PubMed:12628190, ECO:0000269|PubMed:15851025}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:15851025}. |
| Miscellaneous: | |
In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones. |
| Similarity: | |
Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. {ECO:0000255|PROSITE-ProRule:PRU00902}. |
| Sequence caution: | |
Sequence=AAC08316.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.