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PDBsum entry 5juw
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PDB id:
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Transferase
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Title:
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Complex of dot1l with ss148
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Structure:
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Histone-lysine n-methyltransferase, h3 lysine-79 specific. Chain: a. Fragment: unp residues 1-420. Synonym: dot1-like protein,histone h3-k79 methyltransferase,h3-k79- hmtase,lysine n-methyltransferase 4. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: dot1l, kiaa1814, kmt4. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.28Å
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R-factor:
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0.190
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R-free:
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0.215
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Authors:
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W.Yu,W.Tempel,Y.Li,S.S.Spurr,E.D.Bayle,P.V.Fish,M.Schapira, C.H.Arrowsmith,A.M.Edwards,C.Bountra,J.Weigelt,P.J.Brown,Structural Genomics Consortium (Sgc)
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Key ref:
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W.Yu
et al.
Complex of dot1l with ss148.
To be published,
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Date:
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10-May-16
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Release date:
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22-Jun-16
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PROCHECK
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Headers
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References
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Q8TEK3
(DOT1L_HUMAN) -
Histone-lysine N-methyltransferase, H3 lysine-79 specific from Homo sapiens
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Seq:
Struc:
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1537 a.a.
324 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.1.1.360
- [histone H3]-lysine(79) N-trimethyltransferase.
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Reaction:
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L-lysyl79-[histone H3] + 3 S-adenosyl-L-methionine = N6,N6,N6- trimethyl-L-lysyl79-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H+
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L-lysyl(79)-[histone H3]
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+
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3
×
S-adenosyl-L-methionine
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=
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N(6),N(6),N(6)- trimethyl-L-lysyl(79)-[histone H3]
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+
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3
×
S-adenosyl-L-homocysteine
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+
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3
×
H(+)
Bound ligand (Het Group name = )
matches with 86.21% similarity
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
