PDBsum entry 5jlh

Contractile protein

PDB id: 5jlh

Contents

Protein chains

374 a.a.

737 a.a.

135 a.a.

Ligands

ADP ×5

Metals

_MG ×5

PDB id:

5jlh

Name:

Contractile protein

Title:

Cryo-em structure of a human cytoplasmic actomyosin complex at near- atomic resolution

Structure:

Actin, cytoplasmic 2. Chain: a, b, c, d, e. Synonym: gamma-actin. Engineered: yes. Myosin-14,alpha-actinin a. Chain: f, g. Synonym: myosin heavy chain 14,myosin heavy chain,non-muscle iic,non- muscle myosin heavy chain iic,nmhc ii-c, alpha-actinin,actin-binding protein a,f-actin cross-linking protein.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: actg1, actg. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens, dictyostelium discoideum. Human, slime mold. Organism_taxid: 9606, 44689.

Authors:

J.Von Der Ecken,S.M.Heissler,S.Pathan-Chhatbar,D.J.Manstein,S.Raunser

Key ref:

J.von der Ecken et al. (2016). Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution. Nature, 534, 724-728. PubMed id: 27324845 DOI: 10.1038/nature18295

Date:

27-Apr-16 Release date: 15-Jun-16

Protein chains

P63261  (ACTG_HUMAN) -  Actin, cytoplasmic 2 from Homo sapiens

Seq: 375 a.a.

Struc: 374 a.a.

Protein chains

P05095  (ACTNA_DICDI) -  Alpha-actinin A from Dictyostelium discoideum

Seq: 861 a.a.

Struc: 737 a.a.*

Protein chains

Q7Z406  (MYH14_HUMAN) -  Myosin-14 from Homo sapiens

Seq: 1995 a.a.

Struc: 737 a.a.*

Protein chains

No UniProt id for this chain

Struc: 135 a.a.

* PDB and UniProt seqs differ at 264 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B, C, D, E: E.C.3.6.4.- - ?????

DOI no: 10.1038/nature18295

Nature 534:724-728 (2016)

PubMed id: 27324845

Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution.

J.von der Ecken, S.M.Heissler, S.Pathan-Chhatbar, D.J.Manstein, S.Raunser.

ABSTRACT

No abstract given.