 |
PDBsum entry 5jhq
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
462 a.a.
|
|
|
|
|
|
|
|
|
|
|
12 a.a.
|
|
|
|
|
|
|
|
|
|
|
11 a.a.
|
|
|
|
|
|
|
|
|
|
|
11 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Transferase
|
|
|
Title:
|
|
Arcs 1-3 of human tankyrase-1 bound to a peptide derived from irap
|
|
Structure:
|
|
Tankyrase-1. Chain: a, b, c, d. Fragment: unp residues 174-649. Synonym: tank1,adp-ribosyltransferase diphtheria toxin-like 5,artd5, poly [adp-ribose] polymerase 5a,tnks-1,trf1-interacting ankyrin- related adp-ribose polymerase,tankyrase i. Engineered: yes. Peptide derived from insulin-responsive aminopeptidase (irap).
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks, parp5a, parpl, tin1, tinf1, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
|
|
Resolution:
|
|
|
3.20Å
|
R-factor:
|
0.215
|
R-free:
|
0.239
|
|
|
Authors:
|
|
T.Eisemann,J.M.Pascal
|
|
Key ref:
|
|
T.Eisemann
et al.
(2016).
Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.
Structure,
24,
1679-1692.
PubMed id:
DOI:
|
|
|
Date:
|
|
|
21-Apr-16
|
Release date:
|
21-Sep-16
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
O95271
(TNKS1_HUMAN) -
Poly [ADP-ribose] polymerase tankyrase-1 from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
1327 a.a.
462 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Q9UIQ6
(LCAP_HUMAN) -
Leucyl-cystinyl aminopeptidase from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
1025 a.a.
12 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class 2:
|
|
Chains A, B, C, D:
E.C.2.4.2.-
- ?????
|
|
|
|
|
|
|
Enzyme class 3:
|
|
Chains A, B, C, D:
E.C.2.4.2.30
- NAD(+) ADP-ribosyltransferase.
|
|
|
|
|
|
|
Pathway:
|
|
|
|
|
|
|
|
Reaction:
|
|
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H+
|
|
|
|
|
|
NAD(+)
|
+
|
(ADP-D-ribosyl)n-acceptor
|
=
|
nicotinamide
|
+
|
(ADP-D- ribosyl)n+1-acceptor
|
+
|
H(+)
|
|
|
|
|
|
|
|
|
|
Enzyme class 4:
|
|
Chains E, F, G, I:
E.C.3.4.11.3
- cystinyl aminopeptidase.
|
|
|
|
|
|
|
Reaction:
|
|
Release of an N-terminal amino acid, Cys-|-Xaa, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin and vasopressin.
|
|
|
|
|
|
Cofactor:
|
|
Zn(2+)
|
|
|
|
|
|
|
|
|
Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
|
| |
|
DOI no:
|
Structure
24:1679-1692
(2016)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.
|
|
T.Eisemann,
M.McCauley,
M.F.Langelier,
K.Gupta,
S.Roy,
G.D.Van Duyne,
J.M.Pascal.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
| | |
Links
