PDBsum entry 5jeb

Transferase/transferase inhibitor

PDB id: 5jeb

Contents

Protein chain

299 a.a.

Ligands

SO4 ×2

6JS

PDB id:

5jeb

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of egfr tyrosine kinase domain with novel inhibitor of active state of her2

Structure:

Epidermal growth factor receptor. Chain: a. Fragment: unp residues 696-1022. Synonym: proto-oncogenE C-erbb-1,receptor tyrosine-protein kinase erbb-1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Resolution:

3.30Å R-factor: 0.244 R-free: 0.270

Authors:

J.H.Park,M.A.Lemmon

Key ref:

C.J.Novotny et al. (2016). Overcoming resistance to HER2 inhibitors through state-specific kinase binding. Nat Chem Biol, 12, 923-930. PubMed id: 27595329 DOI: 10.1038/nchembio.2171

Date:

18-Apr-16 Release date: 07-Sep-16

Protein chain

P00533  (EGFR_HUMAN) -  Epidermal growth factor receptor from Homo sapiens

Seq: 1210 a.a.

Struc: 299 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1038/nchembio.2171

Nat Chem Biol 12:923-930 (2016)

PubMed id: 27595329

Overcoming resistance to HER2 inhibitors through state-specific kinase binding.

C.J.Novotny, S.Pollari, J.H.Park, M.A.Lemmon, W.Shen, K.M.Shokat.

ABSTRACT

No abstract given.