PDBsum entry 5jde

Structural protein

PDB id

5jde

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Contents

			Protein chains

					260 a.a.

			Waters ×280

PDB id:

5jde

Links

Name:

Structural protein

Title:

Crystal structure of i9-i11 tandem from titin (p1)

Structure:

Titin. Chain: a, b. Synonym: connectin,rhabdomyosarcoma antigen mu-rms-40.14. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ttn. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.90Å

R-factor:

0.173

R-free:

0.219

Authors:

R.Williams,J.Bogomolovas,S.Labiet,O.Mayans

Key ref:

J.Bogomolovas et al. (2016). Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I. Open Biol, 6, . PubMed id: 27683155 DOI: 10.1098/rsob.160114

Date:

16-Apr-16

Release date:

14-Sep-16

PROCHECK

	Headers

	References

Protein chains

Q8WZ42 (TITIN_HUMAN) - Titin from Homo sapiens

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Seq: Struc:					34350 a.a. 260 a.a.*

Key:

PfamA domain

Secondary structure

* PDB and UniProt seqs differ at 1 residue position (black cross)



		Enzyme reactions

Enzyme class:

E.C.2.7.11.1 - non-specific serine/threonine protein kinase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

1.	L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
2.	L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

L-seryl-[protein]	+	ATP	=	O-phospho-L-seryl-[protein]	+	ADP	+	H(+)

L-threonyl-[protein]	+	ATP	=	O-phospho-L-threonyl-[protein]	+	ADP	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

DOI no: 10.1098/rsob.160114	Open Biol 6: (2016)
PubMed id: 27683155

Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I.
J.Bogomolovas, J.R.Fleming, B.R.Anderson, R.Williams, S.Lange, B.Simon, M.M.Khan, R.Rudolf, B.Franke, B.Bullard, D.J.Rigden, H.Granzier, S.Labeit, O.Mayans.

ABSTRACT

No abstract given.