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PDBsum entry 5jdb
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Viral protein
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PDB id
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5jdb
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References listed in PDB file
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Key reference
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Title
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Binding specificity of p[8] vp8 Proteins of rotavirus vaccine strains with histo-Blood group antigens.
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Authors
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X.Sun,
N.Guo,
D.Li,
M.Jin,
Y.Zhou,
G.Xie,
L.Pang,
Q.Zhang,
Y.Cao,
Z.J.Duan.
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Ref.
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Virology, 2016,
495,
129-135.
[DOI no: ]
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PubMed id
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Abstract
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RotaTeq(®) and Rotarix™ are two common human rotavirus (RV) vaccines
currently on the market worldwide. Recent studies indicate histo-blood group
antigens (HBGAs) may be attachment factors for RVs. The P[8] VP8* proteins of
RotaTeq and Rotarix were expressed and purified, and their binding specificities
were evaluated. Saliva-based binding assays showed that the VP8* proteins bound
to the saliva samples of secretors irrespective of ABO blood types. However, in
the oligosaccharide binding assay, the VP8* proteins displayed no specific
binding to the HBGAs tested, including Lewis b and H1. The structure of RotaTeq
P[8] VP8* was solved at 1.9Å. Structural comparisons revealed that the putative
receptor binding site was different to that of other genotypes and displayed a
novel potential binding region. These findings indicate RotaTeq and Rotarix may
have better efficiency in areas with a high percentage of secretors.
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