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PDBsum entry 5j3x
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PDB id:
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Ligase
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Title:
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Structure of c-cbl y371f
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Structure:
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E3 ubiquitin-protein ligase cbl. Chain: a, b, c, d, e, f. Fragment: unp residues 47-435. Synonym: casitas b-lineage lymphoma proto-oncogene,proto-oncogenE C- cbl,ring finger protein 55,signal transduction protein cbl. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: cbl, cbl2, rnf55. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Resolution:
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2.82Å
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R-factor:
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0.215
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R-free:
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0.254
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Authors:
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D.T.Huang,L.Buetow,H.Dou
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Key ref:
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L.Buetow
et al.
(2016).
Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation.
Bmc Biol,
14,
76.
PubMed id:
DOI:
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Date:
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31-Mar-16
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Release date:
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21-Sep-16
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PROCHECK
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Headers
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References
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P22681
(CBL_HUMAN) -
E3 ubiquitin-protein ligase CBL from Homo sapiens
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Seq:
Struc:
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906 a.a.
386 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.2.3.2.27
- RING-type E3 ubiquitin transferase.
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Reaction:
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S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6- ubiquitinyl-[acceptor protein]-L-lysine
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DOI no:
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Bmc Biol
14:76
(2016)
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PubMed id:
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Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation.
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L.Buetow,
G.Tria,
S.F.Ahmed,
A.Hock,
H.Dou,
G.J.Sibbet,
D.I.Svergun,
D.T.Huang.
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ABSTRACT
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Links
