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UniProt functional annotation for P29083 | ||
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| UniProt code: P29083. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. |
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| Subunit: | |
Tetramer of two alpha and two beta chains (PubMed:1956398). Interacts with TAF6/TAFII80 (PubMed:7667268). Interacts with ATF7IP (PubMed:19106100). Interacts with SND1 (PubMed:7651391). {ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:1956398, ECO:0000269|PubMed:7651391, ECO:0000269|PubMed:7667268}. |
| Subunit: | |
(Microbial infection) Interacts with varicella-zoster virus IE63 protein. {ECO:0000269|PubMed:15843171}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:1956398, ECO:0000269|PubMed:7651391}. |
| Similarity: | |
Belongs to the TFIIE alpha subunit family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.