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UniProt functional annotation for P19387 | ||
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| UniProt code: P19387. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}. |
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| Subunit: | |
Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB11/POLR2J and RPB3/POLR2C subunits interact with each other. {ECO:0000269|PubMed:9852112}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:9852112}. |
| Similarity: | |
Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.