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UniProt functional annotation for P35269 | ||
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| UniProt code: P35269. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
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| Subunit: | |
Heterodimer of an alpha and a beta subunit. Interacts with GTF2F2, CTDP1, TAF6/TAFII80 and URI1. Interacts with GTF2B (via C- terminus and preferentially via acetylated form); this interaction prevents binding of GTF2B to GTF2F2 (PubMed:8662660, PubMed:12931194). {ECO:0000269|PubMed:11183778, ECO:0000269|PubMed:12591941, ECO:0000269|PubMed:12737519, ECO:0000269|PubMed:12931194, ECO:0000269|PubMed:7667268, ECO:0000269|PubMed:8662660}. |
| Subcellular location: | |
Nucleus. |
| Induction: | |
Up-regulated in response to enterovirus 71 (EV71) infection. {ECO:0000269|PubMed:16548883}. |
| Ptm: | |
Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases. {ECO:0000269|PubMed:10428810, ECO:0000269|PubMed:8625415}. |
| Similarity: | |
Belongs to the TFIIF alpha subunit family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.