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UniProt functional annotation for P52657 | ||
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| UniProt code: P52657. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. {ECO:0000269|PubMed:11030333}. |
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| Subunit: | |
TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma (By similarity). It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12) (By similarity). Interacts with NCOA6 general coactivator (PubMed:10567404). TFIIA forms a complex with TBP (PubMed:11030333). Interacts with HSF1 (via transactivation domain) (PubMed:11005381). {ECO:0000250|UniProtKB:P52656, ECO:0000269|PubMed:10567404, ECO:0000269|PubMed:11005381, ECO:0000269|PubMed:11030333}. |
| Subunit: | |
(Microbial infection) Interacts with SV40 Large T antigen. {ECO:0000269|PubMed:9632777}. |
| Subcellular location: | |
Nucleus. |
| Similarity: | |
Belongs to the TFIIA subunit 2 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.