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UniProt functional annotation for P52435 | ||
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| UniProt code: P52435. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}. |
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| Subunit: | |
Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. Interacts with AATF. {ECO:0000269|PubMed:10783144, ECO:0000269|PubMed:9852112}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:9852112}. |
| Tissue specificity: | |
Ubiquitously expressed. High expression was found in heart and skeletal muscle. {ECO:0000269|PubMed:11747469}. |
| Similarity: | |
Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.