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UniProt functional annotation for P52434 | ||
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| UniProt code: P52434. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. {ECO:0000269|PubMed:9852112}. |
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| Subunit: | |
Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. Directly interacts with POLR2A. {ECO:0000269|PubMed:16632472, ECO:0000269|PubMed:16809778, ECO:0000269|PubMed:9852112}. |
| Subcellular location: | |
Nucleus, nucleolus {ECO:0000269|PubMed:9852112, ECO:0000269|Ref.6}. |
| Similarity: | |
Belongs to the eukaryotic RPB8 RNA polymerase subunit family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.