UniProt functional annotation for Q60675



	UniProt functional annotation for Q60675

UniProt code: Q60675.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-2 is a subunit of laminin-2 (laminin-211 or merosin), laminin-4 (laminin-221 or S-merosin) and laminin-12 (laminin-213). Interacts with FBLN1, FBLN2 and NID2. {ECO:0000269|PubMed:10022829}.

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.

Domain: Domains VI, IV and G are globular.

Disease: Note=Defects in Lama2 are a cause of murine muscular dystrophy (dy2J).

Sequence caution: Sequence=AAC52165.1; Type=Frameshift; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.


Subunit:		Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-2 is a subunit of laminin-2 (laminin-211 or merosin), laminin-4 (laminin-221 or S-merosin) and laminin-12 (laminin-213). Interacts with FBLN1, FBLN2 and NID2. {ECO:0000269\|PubMed:10022829}.
Subcellular location:		Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
Domain:		The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domain:		Domains VI, IV and G are globular.
Disease:		Note=Defects in Lama2 are a cause of murine muscular dystrophy (dy2J).
Sequence caution:		Sequence=AAC52165.1; Type=Frameshift; Evidence={ECO:0000305};