 |
PDBsum entry 5igl
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Transcription
|
PDB id
|
|
|
|
5igl
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Transcription
|
|
|
Title:
|
|
Crystal structure of the second bromodomain of human taf1l in complex with bromosporine (bsp)
|
|
Structure:
|
|
Transcription initiation factor tfiid subunit 1-like. Chain: a. Synonym: taf(ii)210,tbp-associated factor 1-like,tbp-associated factor 210 kda,transcription initiation factor tfiid 210 kda subunit. Engineered: yes
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Gene: taf1l. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
Resolution:
|
|
|
2.10Å
|
R-factor:
|
0.215
|
R-free:
|
0.294
|
|
|
Authors:
|
|
P.Filippakopoulos,S.Picaud,I.Felletar,T.Krojer,C.Tallant,F.Von Delft, A.M.Edwards,C.H.Arrowsmith,C.Bountra,S.Knapp,Structural Genomics Consortium (Sgc)
|
|
Key ref:
|
|
S.Picaud
et al.
(2016).
Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
Sci Adv,
2,
e1600760.
PubMed id:
DOI:
|
|
|
Date:
|
|
|
28-Feb-16
|
Release date:
|
19-Oct-16
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
Q8IZX4
(TAF1L_HUMAN) -
Transcription initiation factor TFIID subunit 1-like from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
1826 a.a.
139 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
*
PDB and UniProt seqs differ
at 10 residue positions (black
crosses)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
DOI no:
|
Sci Adv
2:e1600760
(2016)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
|
|
S.Picaud,
K.Leonards,
J.P.Lambert,
O.Dovey,
C.Wells,
O.Fedorov,
O.Monteiro,
T.Fujisawa,
C.Y.Wang,
H.Lingard,
C.Tallant,
N.Nikbin,
L.Guetzoyan,
R.Ingham,
S.V.Ley,
P.Brennan,
S.Muller,
A.Samsonova,
A.C.Gingras,
J.Schwaller,
G.Vassiliou,
S.Knapp,
P.Filippakopoulos.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Links
