PDBsum entry 5igk

Transcription

PDB id: 5igk

Contents

Protein chain

127 a.a.

Ligands

EDO

BMF

Waters ×118

PDB id:

5igk

Name:

Transcription

Title:

Crystal structure of the first bromodomain of human brd4 in complex with bromosporine (bsp)

Structure:

Bromodomain-containing protein 4. Chain: a. Synonym: protein hunk1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: brd4, hunk1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.70Å R-factor: 0.158 R-free: 0.200

Authors:

P.Filippakopoulos,S.Picaud,I.Felletar,F.Von Delft,A.M.Edwards, C.H.Arrowsmith,C.Bountra,S.Knapp,Structural Genomics Consortium (Sgc)

Key ref:

S.Picaud et al. (2016). Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia. Sci Adv, 2, e1600760. PubMed id: 27757418 DOI: 10.1126/sciadv.1600760

Date:

28-Feb-16 Release date: 19-Oct-16

Protein chain

O60885  (BRD4_HUMAN) -  Bromodomain-containing protein 4 from Homo sapiens

Seq: 1362 a.a.

Struc: 127 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.?

DOI no: 10.1126/sciadv.1600760

Sci Adv 2:e1600760 (2016)

PubMed id: 27757418

Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.

S.Picaud, K.Leonards, J.P.Lambert, O.Dovey, C.Wells, O.Fedorov, O.Monteiro, T.Fujisawa, C.Y.Wang, H.Lingard, C.Tallant, N.Nikbin, L.Guetzoyan, R.Ingham, S.V.Ley, P.Brennan, S.Muller, A.Samsonova, A.C.Gingras, J.Schwaller, G.Vassiliou, S.Knapp, P.Filippakopoulos.

ABSTRACT

No abstract given.