PDBsum entry 5ido

Transferase

PDB id: 5ido

Contents

Protein chain

471 a.a.

Ligands

UTP

Metals

_MG

_ZN

Waters ×171

PDB id:

5ido

Name:

Transferase

Title:

RNA editing tutase 1 from trypanosoma brucei in complex with utp

Structure:

3' terminal uridylyl transferase. Chain: a. Fragment: residues 189-699. Engineered: yes

Source:

Trypanosoma brucei. Organism_taxid: 5691. Gene: 3' tutase. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.20Å R-factor: 0.250 R-free: 0.288

Authors:

S.Thore,L.T.Rajappa

Key ref:

L.Rajappa-Titu et al. (2016). RNA Editing TUTase 1: structural foundation of substrate recognition, complex interactions and drug targeting. Nucleic Acids Res, 44, 10862-10878. PubMed id: 27744351 DOI: 10.1093/nar/gkw917

Date:

24-Feb-16 Release date: 26-Oct-16

Protein chain

Q8WQX5  (TUT1_TRYBB) -  Terminal uridylyltransferase 1 from Trypanosoma brucei brucei

Seq: 976 a.a.

Struc: 471 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.7.52 - Rna uridylyltransferase.
• Reaction: RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate

RNA(n) + UTP (Bound ligand (Het Group name = UTP) corresponds exactly) = RNA(n)-3'-uridine ribonucleotide + diphosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

DOI no: 10.1093/nar/gkw917

Nucleic Acids Res 44:10862-10878 (2016)

PubMed id: 27744351

RNA Editing TUTase 1: structural foundation of substrate recognition, complex interactions and drug targeting.

L.Rajappa-Titu, T.Suematsu, P.Munoz-Tello, M.Long, Ã.–.Demir, K.J.Cheng, J.R.Stagno, H.Luecke, R.E.Amaro, I.Aphasizheva, R.Aphasizhev, S.Thore.

ABSTRACT

No abstract given.