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PDBsum entry 5ibk
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Protein binding
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PDB id
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5ibk
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Contents |
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141 a.a.
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46 a.a.
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75 a.a.
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48 a.a.
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PDB id:
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| Name: |
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Protein binding
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Title:
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Skp1-f-box in complex with a ubiquitin variant
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Structure:
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S-phase kinase-associated protein 1,s-phase kinase- associated protein 1. Chain: a, d. Fragment: unp resdiues 1-61(deletion 37-42) and 70-163 linked by linker ggsg,unp resdiues 1-61(deletion 37-42) and 70-163 linked by linker ggsg. Synonym: cyclin-a/cdk2-associated protein p19,p19a,organ of corti protein 2,ocp-2,organ of corti protein ii,ocp-ii,RNA polymerase ii elongation factor-like protein,siii,transcription elongation factor b
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: skp1, emc19, ocp2, skp1a, tceb1l. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: fbxw7, fbw7, fbx30, sel10. Gene: ubb.
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Resolution:
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2.50Å
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R-factor:
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0.202
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R-free:
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0.240
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Authors:
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S.Orlicky,F.Sicheri
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Key ref:
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M.Gorelik
et al.
(2016).
Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.
Proc Natl Acad Sci U S A,
113,
3527-3532.
PubMed id:
DOI:
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Date:
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22-Feb-16
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Release date:
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30-Mar-16
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PROCHECK
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Headers
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References
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P63208
(SKP1_HUMAN) -
S-phase kinase-associated protein 1 from Homo sapiens
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Seq:
Struc:
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163 a.a.
141 a.a.*
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Q969H0
(FBXW7_HUMAN) -
F-box/WD repeat-containing protein 7 from Homo sapiens
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Seq:
Struc:
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707 a.a.
46 a.a.
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Enzyme class:
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Chains A, B, F, C, D, E:
E.C.?
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DOI no:
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Proc Natl Acad Sci U S A
113:3527-3532
(2016)
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PubMed id:
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Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.
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M.Gorelik,
S.Orlicky,
M.A.Sartori,
X.Tang,
E.Marcon,
I.Kurinov,
J.F.Greenblatt,
M.Tyers,
J.Moffat,
F.Sicheri,
S.S.Sidhu.
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ABSTRACT
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Links
