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PDBsum entry 5ibc
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Hydrolase/hydrolase inhibitor
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PDB id
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5ibc
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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Caspase 3 v266i
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Structure:
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Caspase-3. Chain: a. Synonym: casp-3,apopain,cysteine protease cpp32,cpp-32,protein yama, srebp cleavage activity 1,sca-1. Engineered: yes. Mutation: yes. Ace-asp-glu-val-ask. Chain: b. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: casp3, cpp32. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Unidentified. Organism_taxid: 32644
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Resolution:
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1.66Å
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R-factor:
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0.175
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R-free:
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0.208
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Authors:
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J.J.Maciag,S.H.Mackenzie,M.B.Tucker,J.L.Schipper,P.D.Swartz,A.C.Clark
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Key ref:
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J.J.Maciag
et al.
(2016).
Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection.
Proc Natl Acad Sci U S A,
113,
E6080.
PubMed id:
DOI:
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Date:
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22-Feb-16
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Release date:
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26-Oct-16
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PROCHECK
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Headers
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References
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P42574
(CASP3_HUMAN) -
Caspase-3 from Homo sapiens
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Seq:
Struc:
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277 a.a.
241 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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DOI no:
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Proc Natl Acad Sci U S A
113:E6080
(2016)
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PubMed id:
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Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection.
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J.J.Maciag,
S.H.Mackenzie,
M.B.Tucker,
J.L.Schipper,
P.Swartz,
A.C.Clark.
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ABSTRACT
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Links
