PDBsum entry 5ia1

Transferase

PDB id: 5ia1

Contents

Protein chain

261 a.a.

Ligands

ZZL

EDO

Waters ×136

PDB id:

5ia1

Name:

Transferase

Title:

Crystal structure of ephrin a2 (epha2) receptor protein kinase with mln8054

Structure:

Ephrin type-a receptor 2. Chain: a. Fragment: unp residues 596-900. Synonym: epithelial cell kinase,tyrosine-protein kinase receptor eck. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9

Resolution:

2.04Å R-factor: 0.183 R-free: 0.223

Authors:

D.Kudlinzki,V.L.Linhard,S.L.Gande,S.Sreeramulu,K.Saxena,S.Heinzlmeir, G.Medard,B.Kuester,H.Schwalbe

Key ref:

S.Heinzlmeir et al. (2016). Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. Acs Chem Biol, 11, 3400-3411. PubMed id: 27768280 DOI: 10.1021/acschembio.6b00709

Date:

21-Feb-16 Release date: 09-Nov-16

Protein chain

P29317  (EPHA2_HUMAN) -  Ephrin type-A receptor 2 from Homo sapiens

Seq: 976 a.a.

Struc: 261 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1021/acschembio.6b00709

Acs Chem Biol 11:3400-3411 (2016)

PubMed id: 27768280

Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.

S.Heinzlmeir, D.Kudlinzki, S.Sreeramulu, S.Klaeger, S.L.Gande, V.Linhard, M.Wilhelm, H.Qiao, D.Helm, B.Ruprecht, K.Saxena, G.Médard, H.Schwalbe, B.Kuster.

ABSTRACT

No abstract given.