PDBsum entry 5i9w

Transferase

PDB id: 5i9w

Contents

Protein chain

267 a.a.

Ligands

ANP

EDO ×2

Waters ×301

PDB id:

5i9w

Name:

Transferase

Title:

Crystal structure of ephrin a2 (epha2) receptor protein kinase with anp

Structure:

Ephrin type-a receptor 2. Chain: a. Synonym: epithelial cell kinase,tyrosine-protein kinase receptor eck. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9

Resolution:

1.36Å R-factor: 0.170 R-free: 0.180

Authors:

D.Kudlinzki,V.L.Linhard,S.L.Gande,S.Sreeramulu,K.Saxena,S.Heinzlmeir, G.Medard,B.Kuester,H.Schwalbe

Key ref:

S.Heinzlmeir et al. (2016). Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. Acs Chem Biol, 11, 3400-3411. PubMed id: 27768280 DOI: 10.1021/acschembio.6b00709

Date:

21-Feb-16 Release date: 09-Nov-16

Protein chain

P29317  (EPHA2_HUMAN) -  Ephrin type-A receptor 2 from Homo sapiens

Seq: 976 a.a.

Struc: 267 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] (Bound ligand (Het Group name = ANP) matches with 81.25% similarity) + ADP + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1021/acschembio.6b00709

Acs Chem Biol 11:3400-3411 (2016)

PubMed id: 27768280

Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.

S.Heinzlmeir, D.Kudlinzki, S.Sreeramulu, S.Klaeger, S.L.Gande, V.Linhard, M.Wilhelm, H.Qiao, D.Helm, B.Ruprecht, K.Saxena, G.Médard, H.Schwalbe, B.Kuster.

ABSTRACT

No abstract given.