PDBsum entry 5i11

Signaling protein

PDB id: 5i11

Contents

Protein chain

56 a.a.

Ligands

PGE

SO4

PEG ×2

ACT

Waters ×19

PDB id:

5i11

Name:

Signaling protein

Title:

Crystal structure of the intertwined form of the src tyrosine kinase sh3 domain t114s-q128r mutant

Structure:

Proto-oncogene tyrosine-protein kinase src. Chain: a. Synonym: proto-oncogenE C-src,pp60c-src,p60-src. Engineered: yes. Mutation: yes

Source:

Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.95Å R-factor: 0.189 R-free: 0.218

Authors:

A.Camara-Artigas

Key ref:

A.Camara-Artigas Crystal structure of the intertwined form of the src tyrosine kinase sh3 domain t114s-Q128r mutant. To be published, .

Date:

05-Feb-16 Release date: 09-Mar-16

Protein chain

P00523  (SRC_CHICK) -  Proto-oncogene tyrosine-protein kinase Src from Gallus gallus

Seq: 533 a.a.

Struc: 56 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site