PDBsum entry 5i0q

Immune system

PDB id: 5i0q

Contents

Protein chains

34 a.a.

125 a.a.

Waters ×132

PDB id:

5i0q

Name:

Immune system

Title:

Structure of human c4b-binding protein alpha chain ccp domains 1 and 2 in complex with the hypervariable region of mutant group a streptococcus m2 (k65a, n66a) protein

Structure:

M protein, serotype 2.1. Chain: a. Fragment: unp residues 42-141. Engineered: yes. C4b-binding protein alpha chain. Chain: b. Fragment: unp residues 49-172. Synonym: c4bp,proline-rich protein,prp. Engineered: yes

Source:

Streptococcus pyogenes. Organism_taxid: 1314. Gene: emml2.1. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: c4bpa, c4bp.

Resolution:

2.29Å R-factor: 0.206 R-free: 0.224

Authors:

C.Z.Buffalo,A.J.Bahn-Suh,P.Ghosh

Key ref:

C.Z.Buffalo et al. (2016). Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein. Nat Microbiol, 1, 16155. PubMed id: 27595425 DOI: 10.1038/nmicrobiol.2016.155

Date:

04-Feb-16 Release date: 20-Jul-16

Protein chain

P50468  (M21_STRPY) -  M protein, serotype 2.1 from Streptococcus pyogenes

Seq: 407 a.a.

Struc: 34 a.a.*

Protein chain

P04003  (C4BPA_HUMAN) -  C4b-binding protein alpha chain from Homo sapiens

Seq: 597 a.a.

Struc: 125 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

DOI no: 10.1038/nmicrobiol.2016.155

Nat Microbiol 1:16155 (2016)

PubMed id: 27595425

Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.

C.Z.Buffalo, A.J.Bahn-Suh, S.P.Hirakis, T.Biswas, R.E.Amaro, V.Nizet, P.Ghosh.

ABSTRACT

No abstract given.