PDBsum entry 5hzd

Transferase

PDB id

5hzd

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Contents

			Protein chain

					476 a.a.

			Ligands

					SO4 ×2

			Metals

					_ZN


					_CL

			Waters ×592

PDB id:

5hzd

Links

Name:

Transferase

Title:

RNA editing tutase 1 from trypanosoma brucei

Structure:

3' terminal uridylyl transferase. Chain: a. Synonym: RNA editing tutase1. Engineered: yes

Source:

Trypanosoma brucei. Organism_taxid: 5691. Gene: 3' tutase. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.60Å

R-factor:

0.168

R-free:

0.200

Authors:

S.Thore,L.T.Rajappa

Key ref:

L.Rajappa-Titu et al. (2016). RNA Editing TUTase 1: structural foundation of substrate recognition, complex interactions and drug targeting. Nucleic Acids Res, 44, 10862-10878. PubMed id: 27744351 DOI: 10.1093/nar/gkw917

Date:

02-Feb-16

Release date:

26-Oct-16

PROCHECK

	Headers

	References

Protein chain

Q8WQX5 (TUT1_TRYBB) - Terminal uridylyltransferase 1 from Trypanosoma brucei brucei

Seq: Struc:

Seq: Struc:					976 a.a. 476 a.a.

Key:

PfamA domain

Secondary structure



		Enzyme reactions

Enzyme class:

E.C.2.7.7.52 - Rna uridylyltransferase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate

RNA(n)	+	UTP	=	RNA(n)-3'-uridine ribonucleotide	+	diphosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

DOI no: 10.1093/nar/gkw917	Nucleic Acids Res 44:10862-10878 (2016)
PubMed id: 27744351

RNA Editing TUTase 1: structural foundation of substrate recognition, complex interactions and drug targeting.
L.Rajappa-Titu, T.Suematsu, P.Munoz-Tello, M.Long, �.�.Demir, K.J.Cheng, J.R.Stagno, H.Luecke, R.E.Amaro, I.Aphasizheva, R.Aphasizhev, S.Thore.

ABSTRACT

No abstract given.