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PDBsum entry 5hjq
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Signaling protein
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PDB id
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5hjq
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PDB id:
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| Name: |
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Signaling protein
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Title:
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Crystal structure of the tbc domain of skywalker/tbc1d24 from drosophila melanogaster in complex with inositol(1,4,5)triphosphate
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Structure:
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Ld10117p. Chain: a. Fragment: tbc domain, residues 1-353. Synonym: skywalker,isoform a,isoform b,isoform h. Engineered: yes. Other_details: contains a n-terminal his-tag
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Source:
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Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: sky, cg9339, dmel_cg9339. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: c41
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Resolution:
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2.30Å
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R-factor:
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0.231
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R-free:
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0.257
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Authors:
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B.Fischer,J.Paesmans,W.Versees
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Key ref:
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B.Fischer
et al.
(2016).
Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function.
Nat Struct Biol,
23,
965-973.
PubMed id:
DOI:
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Date:
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13-Jan-16
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Release date:
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21-Sep-16
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PROCHECK
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Headers
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References
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Q9VIH7
(Q9VIH7_DROME) -
GTPase-activating protein skywalker from Drosophila melanogaster
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Seq:
Struc:
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587 a.a.
284 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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DOI no:
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Nat Struct Biol
23:965-973
(2016)
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PubMed id:
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Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function.
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B.Fischer,
K.Lüthy,
J.Paesmans,
C.De Koninck,
I.Maes,
J.Swerts,
S.Kuenen,
V.Uytterhoeven,
P.Verstreken,
W.Versées.
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ABSTRACT
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Links
