PDBsum entry 5hcz

Transferase/transferase inhibitor

PDB id: 5hcz

Contents

Protein chain

300 a.a.

Ligands

SO4

60E

Waters ×10

PDB id:

5hcz

Name:

Transferase/transferase inhibitor

Title:

Egfr kinase domain mutant "tmlr" with 3-azetidinyl azaindazole compound 21

Structure:

Epidermal growth factor receptor. Chain: a. Synonym: proto-oncogenE C-erbb-1,receptor tyrosine-protein kinase erbb-1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.62Å R-factor: 0.196 R-free: 0.227

Authors:

C.Eigenbrot,C.Yu

Key ref:

B.K.Chan et al. (2016). Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor. J Med Chem, 59, 9080-9093. PubMed id: 27564586 DOI: 10.1021/acs.jmedchem.6b00995

Date:

04-Jan-16 Release date: 07-Sep-16

Protein chain

P00533  (EGFR_HUMAN) -  Epidermal growth factor receptor from Homo sapiens

Seq: 1210 a.a.

Struc: 300 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1021/acs.jmedchem.6b00995

J Med Chem 59:9080-9093 (2016)

PubMed id: 27564586

Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor.

B.K.Chan, E.J.Hanan, K.K.Bowman, M.C.Bryan, D.Burdick, E.Chan, Y.Chen, S.Clausen, T.Dela Vega, J.Dotson, C.Eigenbrot, R.L.Elliott, R.A.Heald, P.S.Jackson, J.D.Knight, H.La, M.D.Lainchbury, S.Malek, H.E.Purkey, G.Schaefer, S.Schmidt, E.M.Seward, S.Sideris, L.Shao, S.Wang, S.K.Yeap, I.Yen, C.Yu, T.P.Heffron.

ABSTRACT

No abstract given.