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UniProt functional annotation for P35845 | ||
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| UniProt code: P35845. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Lipid-binding protein involved in maintenance of intracellular sterol distribution and homeostasis. Binds to phosphoinositides. May be involved in formation of PMN vesicles by altering the membrane lipid composition. {ECO:0000269|PubMed:15173322}. |
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| Subunit: | |
Interacts with NVJ1. {ECO:0000269|PubMed:15367582}. |
| Subcellular location: | |
Cytoplasm. Golgi apparatus membrane. Nucleus outer membrane. Note=Soluble protein that accumulates on the surface of late Golgi membranes and at nucleus-vacuole (NV) junctions, interorganelle interfaces between the nuclear envelope and the vacuole membrane formed during piecemeal microautophagy of the nucleus (PMN). Targeted exclusively to NV junctions in stationary phase. |
| Domain: | |
The ankyrin repeats are required for targeting the protein to the NV junction. {ECO:0000269|PubMed:12727870}. |
| Domain: | |
The PH domain is required for targeting the protein to the late Golgi. {ECO:0000269|PubMed:12727870}. |
| Domain: | |
The FFAT motif is required for interaction with SCS2 and proper localization of the protein. {ECO:0000269|PubMed:12727870}. |
| Similarity: | |
Belongs to the OSBP family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.