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UniProt functional annotation for P26744 | ||
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| UniProt code: P26744. |
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| Organism: | |
Salmonella phage P22 (Bacteriophage P22). |
| Taxonomy: | |
Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Lederbergvirus. |
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| Function: | |
Forms the portal vertex of the capsid (PubMed:21499245). This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection (PubMed:30787152). Procapsid assembly may initiate with a nucleation complex composed of portal and scaffolding proteins (PubMed:30787152). The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel (PubMed:21499245, PubMed:28134243). Switches upon genome packaging from an asymmetrical conformation in the procapsid (PC-portal) to a symmetrical ring in the mature capsid (MV-portal). This change of conformation may serve as a signal for headful packaging (PubMed:28134243). {ECO:0000269|PubMed:21499245, ECO:0000269|PubMed:28134243, ECO:0000269|PubMed:30787152}. |
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| Subunit: | |
Homododecamer (PubMed:21499245). Interacts with the terminase large subunit; this interaction allows the packaging of viral DNA (PubMed:28134243). Interacts with gp4; this interaction participates in the head completion (PubMed:28134243). {ECO:0000269|PubMed:21499245, ECO:0000269|PubMed:28134243}. |
| Subcellular location: | |
Virion {ECO:0000305}. |
| Similarity: | |
Belongs to the p22likevirus portal protein family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.