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UniProt functional annotation for P0A7J3 | ||
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| UniProt code: P0A7J3. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. {ECO:0000269|PubMed:15923259}. |
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| Function: | |
Protein L10 is also a translational repressor protein. It controls the translation of the rplJL-rpoBC operon by binding to its mRNA. {ECO:0000269|PubMed:2448482}. |
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| Subunit: | |
Part of the ribosomal stalk of the 50S ribosomal subunit (PubMed:15923259). The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which 2 L12 dimers bind in a sequential fashion forming a pentameric L10(L12)(L12)2 complex. Two L12 dimers associate with a copy of L10 to form a very strong complex (called L8). {ECO:0000269|PubMed:10094780, ECO:0000269|PubMed:15923259, ECO:0000269|PubMed:25310980, ECO:0000269|PubMed:27906160, ECO:0000269|PubMed:27906161, ECO:0000269|PubMed:27934701, ECO:0000269|PubMed:773698, ECO:0000269|PubMed:782920, ECO:0000269|PubMed:797648}. |
| Mass spectrometry: | |
Mass=17581.1; Method=MALDI; Evidence={ECO:0000269|PubMed:10094780}; |
| Mass spectrometry: | |
Mass=66643; Mass_error=13; Method=Electrospray; Note=Isolated L10(L12)4.; Evidence={ECO:0000269|PubMed:15923259}; |
| Mass spectrometry: | |
Mass=17580; Mass_error=2; Method=Electrospray; Evidence={ECO:0000269|PubMed:15923259}; |
| Miscellaneous: | |
Ribosomal protein L8 appears to be an aggregate of ribosomal proteins L7/L12 and L10. {ECO:0000269|PubMed:773698}. |
| Similarity: | |
Belongs to the universal ribosomal protein uL10 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.