PDBsum entry 5g5l

RNA polymerase

PDB id: 5g5l

Contents

Protein chains

1480 a.a.

1174 a.a.

305 a.a.

58 a.a.

212 a.a.

100 a.a.

193 a.a.

131 a.a.

107 a.a.

69 a.a.

101 a.a.

43 a.a.

105 a.a.

145 a.a.

463 a.a.

Metals

_ZN ×7

References listed in PDB file

Key reference

• Title: Rna polymerase I-Rrn3 complex at 4.8 å resolution.
• Authors: C.Engel, J.Plitzko, P.Cramer.
• Ref.: Nat Commun, 2016, 7, 12129. [DOI no: 10.1038/ncomms12129]
• PubMed id: 27418309

Abstract

Transcription of ribosomal DNA by RNA polymerase I (Pol I) requires the initiation factor Rrn3. Here we report the cryo-EM structure of the Pol I-Rrn3 complex at 4.8 Å resolution. The structure reveals how Rrn3 binding converts an inactive Pol I dimer into an initiation-competent monomeric complex and provides insights into the mechanisms of Pol I-specific initiation and regulation.