PDBsum entry 5ful

Transferase

PDB id: 5ful

Contents

Protein chain

339 a.a.

Ligands

SAH

PG4

EDO ×2

Metals

_CA ×2

_CL

Waters ×309

PDB id:

5ful

Name:

Transferase

Title:

Crystal structure of mus musculus protein arginine methyltransferase 2 with sah

Structure:

Protein arginine n-methyltransferase 2. Chain: a. Engineered: yes. Mutation: yes

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Resolution:

1.89Å R-factor: 0.167 R-free: 0.192

Authors:

V.Cura,N.Troffer-Charlier,N.Marechal,L.Bonnefond,J.Cavarelli

Key ref:

V.Cura et al. (2017). Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors. Febs J, 284, 77-96. PubMed id: 27879050 DOI: 10.1111/febs.13953

Date:

27-Jan-16 Release date: 09-Nov-16

Protein chain

Q3UKX1  (Q3UKX1_MOUSE) -  Protein arginine N-methyltransferase 2 from Mus musculus

Seq: 445 a.a.

Struc: 339 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.1.1.125 - Transferred entry: 2.1.1.319, 2.1.1.320, 2.1.1.321 and 2.1.1.322.
• Reaction: S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone]

S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine (Bound ligand (Het Group name = SAH) corresponds exactly) + N(omega)-methyl-arginine-[histone]

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1111/febs.13953

Febs J 284:77-96 (2017)

PubMed id: 27879050

Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.

V.Cura, N.Marechal, N.Troffer-Charlier, J.M.Strub, M.J.van Haren, N.I.Martin, S.Cianférani, L.Bonnefond, J.Cavarelli.

ABSTRACT

No abstract given.