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UniProt functional annotation for P41895 | ||
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| UniProt code: P41895. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
TFIIF is a general transcription initiation factor that binds to RNA polymerase II. Its functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation. {ECO:0000269|PubMed:1331085}. |
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| Subunit: | |
TFIIF is composed of three different subunits: TFG1/RAP74, TFG2/RAP30 and TAF14. |
| Subcellular location: | |
Nucleus. |
| Ptm: | |
Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases. {ECO:0000250}. |
| Miscellaneous: | |
Present with 1920 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the TFIIF alpha subunit family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.