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PDBsum entry 5fk9
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Immune system
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PDB id
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5fk9
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Contents |
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198 a.a.
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241 a.a.
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216 a.a.
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References listed in PDB file
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Key reference
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Title
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Two common structural motifs for tcr recognition by staphylococcal enterotoxins.
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Authors
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K.E.Rödström,
P.Regenthal,
C.Bahl,
A.Ford,
D.Baker,
K.Lindkvist-Petersson.
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Ref.
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Sci Rep, 2016,
6,
25796.
[DOI no: ]
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PubMed id
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Abstract
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Superantigens are toxins produced by Staphylococcus aureus, called
staphylococcal enterotoxins (abbreviated SEA to SEU). They can cross-link the T
cell receptor (TCR) and major histocompatibility complex class II, triggering a
massive T cell activation and hence disease. Due to high stability and toxicity,
superantigens are potential agents of bioterrorism. Hence, antagonists may not
only be useful in the treatment of disease but also serve as countermeasures to
biological warfare. Of particular interest are inhibitors against SEA and SEB.
SEA is the main cause of food poisoning, while SEB is a common toxin
manufactured as a biological weapon. Here, we present the crystal structures of
SEA in complex with TCR and SEE in complex with the same TCR, complemented with
computational alanine-scanning mutagenesis of SEA, SEB, SEC3, SEE, and SEH. We
have identified two common areas that contribute to the general TCR binding for
these superantigens. This paves the way for design of single antagonists
directed towards multiple toxins.
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