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PDBsum entry 5fh6
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Transcription
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PDB id
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5fh6
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References listed in PDB file
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Key reference
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Title
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Identification and development of 2,3-Dihydropyrrolo[1,2-A]quinazolin-5(1h)-One inhibitors targeting bromodomains within the switch/sucrose nonfermenting complex.
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Authors
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C.L.Sutherell,
C.Tallant,
O.P.Monteiro,
C.Yapp,
J.E.Fuchs,
O.Fedorov,
P.Siejka,
S.Müller,
S.Knapp,
J.D.Brenton,
P.E.Brennan,
S.V.Ley.
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Ref.
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J Med Chem, 2016,
59,
5095-5101.
[DOI no: ]
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PubMed id
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Abstract
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Bromodomain containing proteins PB1, SMARCA4, and SMARCA2 are important
components of SWI/SNF chromatin remodeling complexes. We identified bromodomain
inhibitors that target these proteins and display unusual binding modes
involving water displacement from the KAc binding site. The best compound binds
the fifth bromodomain of PB1 with a KD of 124 nM, SMARCA2B and SMARCA4 with KD
values of 262 and 417 nM, respectively, and displays excellent selectivity over
bromodomains other than PB1, SMARCA2, and SMARCA4.
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