PDBsum entry 5fdx

Transferase

PDB id: 5fdx

Contents

Protein chains

280 a.a.

Ligands

5X1 ×2

EDO ×5

PEG ×3

Waters ×141

PDB id:

5fdx

Name:

Transferase

Title:

Structure of ddr1 receptor tyrosine kinase in complex with d2164 inhibitor at 2.65 angstroms resolution.

Structure:

Epithelial discoidin domain-containing receptor 1. Chain: a, b. Fragment: unp residues 601-913. Synonym: epithelial discoidin domain receptor 1,cd167 antigen-like family member a,cell adhesion kinase,discoidin receptor tyrosine kinase,hgk2,mammary carcinoma kinase 10,mck-10,protein-tyrosine kinase 3a,protein-tyrosine kinase rtk-6,trk e,tyrosine kinase ddr, tyrosine-protein kinase cak,ddr1 receptor tyrosine kinase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.65Å R-factor: 0.198 R-free: 0.273

Authors:

S.G.Bartual,D.M.Pinkas,Z.Wang,K.Ding,P.Mahajan,K.Kupinska, S.Mukhopadhyay,C.Strain-Damerell,R.Chalk,O.Borkowska,R.Talon, J.Kopec,E.Williams,C.Tallant,A.Chaikuad,F.Sorell,J.Newman,N.Burgess- Brown,F.Von Delft,C.H.Arrowsmith,A.M.Edwards,C.Bountra,A.Bullock, Structural Genomics Consortium (Sgc)

Key ref:

S.G.Bartual et al. Structure of ddr1 receptor tyrosine kinase in complex d2164 inhibitor at 2.65 angstroms resolution.. To be published, .

Date:

16-Dec-15 Release date: 26-Oct-16

Protein chains

Q08345  (DDR1_HUMAN) -  Epithelial discoidin domain-containing receptor 1 from Homo sapiens

Seq: 913 a.a.

Struc: 280 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site