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PDBsum entry 5fbx
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Transcription
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PDB id
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5fbx
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PDB id:
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| Name: |
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Transcription
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Title:
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Crystal structure of the first bromodomain of human brd4 in complex with pnz5 isoxazole inhibitor
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Structure:
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Bromodomain-containing protein 4. Chain: a. Fragment: 1st bromodomain, unp residues 44-168. Synonym: protein hunk1. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: brd4, hunk1. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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1.85Å
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R-factor:
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0.215
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R-free:
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0.267
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Authors:
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C.Tallant,P.G.K.Clark,P.Siejka,O.Fedorov,R.Nowak,V.Srikannathasan, F.Von Delft,C.H.Arrowsmith,A.M.Edwards,C.Bountra,S.Muller, P.E.Brennan,D.Dixon,S.Knapp
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Key ref:
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C.Tallant
et al.
Crystal structure of the first bromodomain of human b complex with pnz5 isoxazole inhibitor.
To be published,
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Date:
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14-Dec-15
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Release date:
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30-Dec-15
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PROCHECK
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Headers
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References
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O60885
(BRD4_HUMAN) -
Bromodomain-containing protein 4 from Homo sapiens
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Seq:
Struc:
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1362 a.a.
127 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Links
