UniProt functional annotation for Q14005



	UniProt functional annotation for Q14005

UniProt code: Q14005.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.

Function: [Isoform 1]: may act as a scaffolding protein that anchors ion channels in the membrane.

Function: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA- binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

Subunit: Homotetramer (Probable). According to PubMed:9699630, the formation of a homotetrameric protein complex is not required for the chemo-attractant function. Isoform 3 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GRIN2A. Isoform 3 interacts with GABPB1. Isoform 3 interacts (via PDZ 3 domain) with HDAC3. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C (By similarity). {ECO:0000250, ECO:0000269|PubMed:12923170, ECO:0000269|PubMed:18097041, ECO:0000269|PubMed:7910967, ECO:0000305}.

Subunit: (Microbial infection) Isoform 3 interacts with HTLV-1 tax. {ECO:0000269|PubMed:12620798}.

Subcellular location: [Interleukin-16]: Secreted.

Subcellular location: [Isoform 1]: Cytoplasm {ECO:0000250}.

Subcellular location: [Isoform 3]: Cytoplasm. Nucleus.

Tissue specificity: [Isoform 3]: Expressed in hemopoietic tissues, such as resting T-cells, but undetectable during active T-cell proliferation.

Induction: [Isoform 3]: Down-regulated in T-cells after TCR activation. {ECO:0000269|PubMed:11276202}.

Ptm: [Isoform 3]: Synthesized as a chemo-attractant inactive precursor in hemopoietic tissues, and proteolytically cleaved by caspase-3 to yield IL-16. {ECO:0000269|PubMed:9422780}.

Miscellaneous: [Isoform 1]: Produced by alternative promoter usage. Is probably proteolytically processed to yield IL-16.

Miscellaneous: [Isoform 2]: Produced by alternative splicing of isoform 1. Is probably proteolytically processed to yield IL-16. {ECO:0000305}.

Miscellaneous: [Isoform 3]: Produced by alternative promoter usage. Is proteolytically processed to yield IL-16. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.



Function:		[Isoform 1]: may act as a scaffolding protein that anchors ion channels in the membrane.



Function:		Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA- binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.


Subunit:		Homotetramer (Probable). According to PubMed:9699630, the formation of a homotetrameric protein complex is not required for the chemo-attractant function. Isoform 3 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GRIN2A. Isoform 3 interacts with GABPB1. Isoform 3 interacts (via PDZ 3 domain) with HDAC3. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C (By similarity). {ECO:0000250, ECO:0000269\|PubMed:12923170, ECO:0000269\|PubMed:18097041, ECO:0000269\|PubMed:7910967, ECO:0000305}.
Subunit:		(Microbial infection) Isoform 3 interacts with HTLV-1 tax. {ECO:0000269\|PubMed:12620798}.
Subcellular location:		[Interleukin-16]: Secreted.
Subcellular location:		[Isoform 1]: Cytoplasm {ECO:0000250}.
Subcellular location:		[Isoform 3]: Cytoplasm. Nucleus.
Tissue specificity:		[Isoform 3]: Expressed in hemopoietic tissues, such as resting T-cells, but undetectable during active T-cell proliferation.
Induction:		[Isoform 3]: Down-regulated in T-cells after TCR activation. {ECO:0000269\|PubMed:11276202}.
Ptm:		[Isoform 3]: Synthesized as a chemo-attractant inactive precursor in hemopoietic tissues, and proteolytically cleaved by caspase-3 to yield IL-16. {ECO:0000269\|PubMed:9422780}.
Miscellaneous:		[Isoform 1]: Produced by alternative promoter usage. Is probably proteolytically processed to yield IL-16.
Miscellaneous:		[Isoform 2]: Produced by alternative splicing of isoform 1. Is probably proteolytically processed to yield IL-16. {ECO:0000305}.
Miscellaneous:		[Isoform 3]: Produced by alternative promoter usage. Is proteolytically processed to yield IL-16. {ECO:0000305}.