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UniProt functional annotation for Q8T045 | ||
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| UniProt code: Q8T045. |
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| Organism: | |
Drosophila melanogaster (Fruit fly). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. |
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| Function: | |
Protein O-glucosyltransferase. Catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue found in the consensus sequence C-X-S-X-[PA]-C in epidermal growth factor-like repeats (PubMed:27428513). Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch. {ECO:0000269|PubMed:18243100, ECO:0000269|PubMed:27428513}. |
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| Pathway: | |
Protein modification; protein glycosylation. {ECO:0000269|PubMed:27428513}. |
| Subcellular location: | |
Endoplasmic reticulum lumen {ECO:0000255|PROSITE- ProRule:PRU10138, ECO:0000269|PubMed:18243100}. |
| Developmental stage: | |
Expressed both maternally and zygotically. {ECO:0000269|PubMed:18243100}. |
| Disruption phenotype: | |
Flies exhibit a temperature-dependent loss of Notch signaling, resulting in bristle loss (PubMed:18243100). Defects in muscle development (PubMed:27807076). {ECO:0000269|PubMed:18243100, ECO:0000269|PubMed:27807076}. |
| Similarity: | |
Belongs to the glycosyltransferase 90 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.