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UniProt functional annotation for Q96D42 | ||
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| UniProt code: Q96D42. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair. {ECO:0000250, ECO:0000269|PubMed:17471468}. |
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| Function: | |
(Microbial infection) Acts as a receptor for Hepatitis A virus. {ECO:0000269|PubMed:29437974, ECO:0000269|PubMed:9658108}. |
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| Function: | |
(Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:21536871). Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP (PubMed:26487564). {ECO:0000269|PubMed:21536871, ECO:0000269|PubMed:26487564}. |
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| Function: | |
(Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane. {ECO:0000269|PubMed:23084921}. |
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| Function: | |
(Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E. {ECO:0000269|PubMed:32641828}. |
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| Subunit: | |
(Microbial infection) Interacts with hepatitis A virus capsid proteins. {ECO:0000269|PubMed:29437974, ECO:0000269|PubMed:9658108}. |
| Subunit: | |
(Microbial infection) Interacts with Ebolavirus envelope glycoprotein GP. {ECO:0000269|PubMed:26487564}. |
| Subunit: | |
(Microbial infection) Interacts with Zika virus envelope protein E. {ECO:0000269|PubMed:26487564}. |
| Subcellular location: | |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Tissue specificity: | |
Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses. {ECO:0000269|PubMed:9658108}. |
| Induction: | |
Up-regulated in the kidney in renal diseases (at protein level). {ECO:0000269|PubMed:17471468}. |
| Polymorphism: | |
The region containing tandem repeats is polymorphic and the sequence shown here corresponds to the most common allele (PubMed:14534576). An association between hepatitis A virus (HAV) infection and atopic diseases has been observed in individuals with that allele (PubMed:14534576). Allelic variation does not affect HAV- infection rates in Caucasians, Asians and African Americans (PubMed:14534576). {ECO:0000269|PubMed:14534576}. |
| Miscellaneous: | |
The extracellular part of the protein can be cleaved and detected in urine and is in correlation with the expression in the kidney. |
| Similarity: | |
Belongs to the immunoglobulin superfamily. TIM family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.