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UniProt functional annotation for A6ND01 | ||
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| UniProt code: A6ND01. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate. {ECO:0000250|UniProtKB:Q9EQF4}. |
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| Subunit: | |
Monomer (PubMed:27309808). Interacts with IZUMO1; the interaction is direct. IZUMO1 and IZUMO1R/JUNO form a complex with 1:1 stoichiometry (PubMed:24739963, PubMed:27309818, PubMed:27309808). {ECO:0000269|PubMed:24739963, ECO:0000269|PubMed:27309808, ECO:0000269|PubMed:27309818}. |
| Subcellular location: | |
Cell membrane {ECO:0000250|UniProtKB:Q9EQF4}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9EQF4}. Note=GPI- anchored at the oolemma. {ECO:0000250|UniProtKB:Q9EQF4}. |
| Ptm: | |
The protein is rapidly cleaved following fertilization, being only weakly detectable in zona-intact fertilized eggs at telophase II and undetectable at the pronuclear stage. Sheding is probably required to block to polyspermy and ensuring egg fusion with a single sperm. {ECO:0000250|UniProtKB:Q9EQF4}. |
| Miscellaneous: | |
[Isoform 2]: Gene prediction based on similarity to orthologs. {ECO:0000305}. |
| Similarity: | |
Belongs to the folate receptor family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.