PDBsum entry 5f0a

Transferase/transferase inhibitor

PDB id: 5f0a

Contents

Protein chain

811 a.a.

Ligands

1FB

Waters ×179

PDB id:

5f0a

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of pvx_084705 with bound 1-tert-butyl-3-(3- chlorophenoxy)-1h-pyrazolo[3,4-d]pyrimidin-4-amine inhibitor

Structure:

Cgmp-dependent protein kinase, putative. Chain: a. Engineered: yes

Source:

Plasmodium vivax (strain salvador i). Organism_taxid: 126793. Strain: salvador i. Gene: pvx_084705. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Resolution:

2.60Å R-factor: 0.210 R-free: 0.242

Authors:

J.R.Walker,A.K.Wernimont,H.He,A.Seitova,P.Loppnau,L.D.Sibley, S.Graslund,A.Hutchinson,C.Bountra,J.Weigelt,A.M.Edwards, C.H.Arrowsmith,R.Hui,M.El Bakkouri,Structural Genomics Consortium (Sgc)

Key ref:

J.R.Walker et al. Crystal structure of pvx_084705 with bound inhibitor. To be published, .

Date:

27-Nov-15 Release date: 16-Dec-15

Supersedes:

4wjc

Protein chain

A5K0N4  (A5K0N4_PLAVS) -  cGMP-dependent protein kinase from Plasmodium vivax (strain Salvador I)

Seq: 846 a.a.

Struc: 811 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.11.12 - cGMP-dependent protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site