UniProt functional annotation for G3XCV0



	UniProt functional annotation for G3XCV0

UniProt code: G3XCV0.

Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1).

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.

Function: AAA+ ATPase enhancer-binding protein that acts as a transcription regulator and plays a role in the modulation of mucin adhesion and flagellar gene expression (PubMed:9287015, PubMed:11673434, PubMed:26362077). In addition to flagella genes, regulates also expression of biofilm-related genes (PubMed:22581773). Functions as a transcriptional repressor in the absence of c-di-GMP and as an activator when c-di-GMP is present (PubMed:22581773). {ECO:0000269|PubMed:11673434, ECO:0000269|PubMed:22581773, ECO:0000269|PubMed:26362077, ECO:0000269|PubMed:9287015}.

Activity regulation: C-di-GMP interaction leads to active site obstruction, hexameric ring destabilization thus relieving DNA bending and activating gene transcription. {ECO:0000269|PubMed:26712005}.

Subunit: Forms homodimers (PubMed:26362077). Forms homohexamers that inhibit transcription initiation (PubMed:26712005). Interacts with FleN; this complex is formed in the presence as well as in the absence of c-di-GMP or ATP (PubMed:22581773). {ECO:0000269|PubMed:22581773, ECO:0000269|PubMed:26362077, ECO:0000269|PubMed:26712005}.

Domain: The N-terminal FleQ domain mediates dimerization and is essential for function. {ECO:0000269|PubMed:26362077}.

Disruption phenotype: Deletion results in the concomitant loss of motility, mucin adhesion, and the ability to synthesize flagellin. {ECO:0000269|PubMed:26362077, ECO:0000269|PubMed:9287015}.

Annotations taken from UniProtKB at the EBI.


Organism:		Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.



Function:		AAA+ ATPase enhancer-binding protein that acts as a transcription regulator and plays a role in the modulation of mucin adhesion and flagellar gene expression (PubMed:9287015, PubMed:11673434, PubMed:26362077). In addition to flagella genes, regulates also expression of biofilm-related genes (PubMed:22581773). Functions as a transcriptional repressor in the absence of c-di-GMP and as an activator when c-di-GMP is present (PubMed:22581773). {ECO:0000269\|PubMed:11673434, ECO:0000269\|PubMed:22581773, ECO:0000269\|PubMed:26362077, ECO:0000269\|PubMed:9287015}.


Activity regulation:		C-di-GMP interaction leads to active site obstruction, hexameric ring destabilization thus relieving DNA bending and activating gene transcription. {ECO:0000269\|PubMed:26712005}.
Subunit:		Forms homodimers (PubMed:26362077). Forms homohexamers that inhibit transcription initiation (PubMed:26712005). Interacts with FleN; this complex is formed in the presence as well as in the absence of c-di-GMP or ATP (PubMed:22581773). {ECO:0000269\|PubMed:22581773, ECO:0000269\|PubMed:26362077, ECO:0000269\|PubMed:26712005}.
Domain:		The N-terminal FleQ domain mediates dimerization and is essential for function. {ECO:0000269\|PubMed:26362077}.
Disruption phenotype:		Deletion results in the concomitant loss of motility, mucin adhesion, and the ability to synthesize flagellin. {ECO:0000269\|PubMed:26362077, ECO:0000269\|PubMed:9287015}.