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UniProt functional annotation for Q1EG27 | ||
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| UniProt code: Q1EG27. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Probable actin-based motor with a protein kinase activity (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern (PubMed:26754646). Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (PubMed:22264607). {ECO:0000250|UniProtKB:Q8WXR4, ECO:0000269|PubMed:22264607, ECO:0000269|PubMed:26754646}. |
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| Catalytic activity: | |
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; |
| Catalytic activity: | |
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; |
| Subunit: | |
Interacts (via C-terminus) with ESPN (PubMed:26785147, PubMed:26926603). Interacts (via C-terminus) with ESPNL (PubMed:26926603). {ECO:0000269|PubMed:26785147, ECO:0000269|PubMed:26926603}. |
| Subcellular location: | |
Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, stereocilium {ECO:0000269|PubMed:26754646}. |
| Tissue specificity: | |
Expressed in the cochlear hair cells (at protein level) (PubMed:26754646). Expressed in utricle hair bundles (at protein level) (PubMed:26926603). {ECO:0000269|PubMed:26754646, ECO:0000269|PubMed:26926603}. |
| Disruption phenotype: | |
MYO3B single knockout mice do not exhibit early hearing impairment whereas mice with a double knockout of MYO3A and MYO3B are profoundly deaf at 1 month of age. Cochlear hair bundles have abnormally long stereocilia and show dynamic shape defects during development. {ECO:0000269|PubMed:26754646}. |
| Similarity: | |
In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. {ECO:0000305}. |
| Similarity: | |
In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.