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UniProt functional annotation for P20702 | ||
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| UniProt code: P20702. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. |
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| Subunit: | |
Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2. {ECO:0000269|PubMed:20033057}. |
| Subcellular location: | |
Membrane; Single-pass type I membrane protein. |
| Tissue specificity: | |
Predominantly expressed in monocytes and granulocytes. |
| Domain: | |
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. |
| Similarity: | |
Belongs to the integrin alpha chain family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.