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PDBsum entry 5emm
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Transferase/transferase inhibitor
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PDB id
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5emm
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References listed in PDB file
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Key reference
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Title
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Structure and property guided design in the identification of prmt5 tool compound epz015666.
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Authors
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K.W.Duncan,
N.Rioux,
P.A.Boriack-Sjodin,
M.J.Munchhof,
L.A.Reiter,
C.R.Majer,
L.Jin,
L.D.Johnston,
E.Chan-Penebre,
K.G.Kuplast,
M.Porter scott,
R.M.Pollock,
N.J.Waters,
J.J.Smith,
M.P.Moyer,
R.A.Copeland,
R.Chesworth.
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Ref.
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ACS Med Chem Lett, 2016,
7,
162-166.
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PubMed id
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Abstract
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The recent publication of a potent and selective inhibitor of protein
methyltransferase 5 (PRMT5) provides the scientific community with in
vivo-active tool compound EPZ015666 (GSK3235025) to probe the underlying
pharmacology of this key enzyme. Herein, we report the design and optimization
strategies employed on an initial hit compound with poor in vitro clearance to
yield in vivo tool compound EPZ015666 and an additional potent in vitro tool
molecule EPZ015866 (GSK3203591).
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